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Adenosine: A Key Link between Metabolism and Brain ActivityFrom Springer
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Homeostasis of key metabolites and metabolic health affects all bodily systems. �Not surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in the central nervous system – including developmental disorders, acute nervous system injury, and neurodegenerative disorders.� Accordingly, metabolism-based therapies offer significant promise as new category of treatment options designed to limit, delay or reverse the disease process by reconstructing homeostatic functions.� Increasingly it is appreciated that restoring metabolic health could promote normal nervous system activity, and improve behavior and cognition.�
Adenosine:� A Key Link Between Metabolism and Central Nervous System Activity focusses on diverse aspects of adenosine, an evolutionarily conserved homeostatic bioenergetic regulator in the central nervous system.� Because of its interrelationship with ATP (adenosine triphosphate), adenosine is integral to cell metabolism.� At the same time, adenosine influences neuronal activity directly via receptors, and is involved in biochemical processes related to gene expression.� Thus, adenosine is uniquely placed as a reciprocal and rapid link between changes in metabolism and changes in neuronal activity, and, on a longer time scale, to changes in gene expression and long term changes in cell function. �Leaders in the field feature basic research on adenosine at the cellular level in the central nervous system, and relate these findings to its recognized potential in diverse acute and chronic disorders.� This comprehensive overview of adenosine also highlights emerging adenosine-based treatments and associated opportunities for central nervous system disorders.
- Published on: 2012-08-30
- Released on: 2012-08-30
- Format: Kindle eBook
Review
From the book reviews:
“This textbook catalogues the debate concerning adenosine metabolism and it’s possible role in ischemia, trauma, and epilepsy animal models. … I do recommend this book to cerebral ischemia researchers.” (Joseph J. Grenier, Amazon.com, August, 2014)
From the Back Cover
Homeostasis of key metabolites and metabolic health affects all bodily systems. �Not surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in the central nervous system – including developmental disorders, acute nervous system injury, and neurodegenerative disorders.� Accordingly, metabolism-based therapies offer significant promise as new category of treatment options designed to limit, delay or reverse the disease process by reconstructing homeostatic functions.� Increasingly it is appreciated that restoring metabolic health could promote normal nervous system activity, and improve behavior and cognition.�
Adenosine:� A Key Link Between Metabolism and Central Nervous System Activity focusses on diverse aspects of adenosine, an evolutionarily conserved homeostatic bioenergetic regulator in the central nervous system.� Because of its interrelationship with ATP (adenosine triphosphate), adenosine is integral to cell metabolism.� At the same time, adenosine influences neuronal activity directly via receptors, and is involved in biochemical processes related to gene expression.� Thus, adenosine is uniquely placed as a reciprocal and rapid link between changes in metabolism and changes in neuronal activity, and, on a longer time scale, to changes in gene expression and long term changes in cell function. �Leaders in the field feature basic research on adenosine at the cellular level in the central nervous system, and relate these findings to its recognized potential in diverse acute and chronic disorders.� This comprehensive overview of adenosine also highlights emerging adenosine-based treatments and associated opportunities for central nervous system disorders.Most helpful customer reviews
0 of 0 people found the following review helpful.
CNS Adenosine in Trauma, Ischemia, & Epilepsy
By Joseph J Grenier
CNS Adenosine
Springer New York Berlin Heidelberg
Joseph J Grenier MD PhD
This textbook catalogues the debate concerning adenosine metabolism and it’s possible role in ischemia, trauma, and epilepsy animal models. We should use MR spectroscopy to help substantiate many of the animal research findings. This is yet another argument for and against to a certain degree. I do recommend this book to cerebral ischemia researchers. Translational Ischemia Research should however be continued. ATP, GTP and the cytosolic cyl mediators should be looked for in the same brain sections. Penumbra research should continue in this area.
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